Is there a direct train?

No, there is no direct train service to Sherbrooke.

No, there are no toll roads on this route.

Is Sherbrooke a good place to visit?

Yes, it offers a great mix of culture and nature.

Yes, regional bus services are available throughout the Eastern Townships.

Gananoque

Sherbrooke

Driving

Gananoque to Sherbrooke

Updated: 26 May 2026

The journey from Gananoque to Sherbrooke covers 450 km through Ontario and Quebec. Driving is the most practical method, taking approximately 5 hours via Highway 401 and Highway 20. Sherbrooke is a major city in the Eastern Townships of Quebec, known for its vibrant culture and beautiful scenery. This route is a long but scenic drive through the heart of the St. Lawrence River valley. It is a popular path for those traveling between Ontario and the Eastern Townships.

Total Distance: 450 km driving distance; 400 km straight-line air distance.

Fastest Way

Driving is the fastest method, taking approximately 5 hours.

Cheapest Way

Driving is the most cost-effective for groups of two or more.

Compare Gananoque to Sherbrooke Routes

Driving

Direct

Duration

5 hours

Avg Price

100-140 CAD in fuel

Operator

Personal Vehicle

Route

Highway 401 East to Highway 20 East.

Use the Highway 55 exit for easy access to Sherbrooke.

Travel Tips

Traffic
The 401 and 20 through the Montreal area are extremely busy; avoid peak hours if possible.
Parking
Downtown Sherbrooke has several public parking lots available for visitors.
Navigation
Use a GPS to find the best route through the local streets of Sherbrooke.
Language
French is the primary language in Sherbrooke; basic knowledge is helpful.
Booking
Book your accommodation in advance, especially during peak tourist seasons.

Safety Tips

Highway Safety
Stay in the middle lanes on the highway to avoid merging traffic at busy interchanges.
Pedestrian Safety
Be aware of cyclists on the local trails.
Emergency
Keep your phone charged and have a roadside assistance plan.
Night Driving
Ensure your vehicle's lights are working properly for highway travel.