The distance between Gananoque and Prescott is approximately 65 kilometers. You can drive this route in about 45 minutes via Highway 401. This is a straightforward drive along the St. Lawrence River. Prescott is a historic town on the river. It is a very common route for those traveling along the 401 corridor.
Total Distance: 65 km driving distance; 60 km straight-line air distance.
The 401 is the most direct route.
Summer for the scenic river views.