St. Thomas is a historic railway city in Southwestern Ontario. The drive from Lancaster is approximately 650 kilometers, following the Highway 401 corridor past Toronto and London. This is a long but straightforward drive that takes about 7 hours. Ensure you plan for traffic delays in the GTA.
Total Distance: 650 km driving distance; 580 km straight-line air distance.
Take the exit for Highway 4 towards St. Thomas from London.
May to September for pleasant weather and outdoor activities.