Yes, it is one of the busiest highways in North America.

How long does it take?

Usually 3.5 to 4 hours depending on traffic.

Yes, but it requires multiple transfers and is not recommended.

Yes, it is generally considered a safe city for travelers.

What is the best time to leave?

Early morning to beat the GTA rush hour.

Amherstburg

Mississauga

Driving

Amherstburg to Mississauga

Updated: 26 May 2026

The route from Amherstburg to Mississauga covers roughly 340 kilometers along the Highway 401 corridor. This is a major transit artery connecting Southwestern Ontario to the Greater Toronto Area. Driving takes approximately 3.5 to 4 hours depending on traffic entering the GTA. You will pass through major hubs like London and Kitchener before reaching the Mississauga city limits.

Total Distance: 340 km driving distance, 290 km straight-line air distance.

Fastest Way

Driving during off-peak hours is the fastest method.

Cheapest Way

Driving your own car is the most economical way to reach Mississauga.

Compare Amherstburg to Mississauga Routes

Driving

Direct

Duration

3 hours 45 mins

Avg Price

$60-$80 in fuel

Operator

Personal Vehicle

Route

Highway 401 East directly into Mississauga.

The 401 through Mississauga is one of the busiest highways in North America.

Travel Tips

Avoid Rush Hour
Try to arrive in Mississauga before 3:00 PM or after 7:00 PM to avoid heavy GTA traffic.
Highway 401 Lanes
Use the express lanes if available to bypass local traffic through the city.
Public Transit
MiWay provides extensive bus service throughout Mississauga once you arrive.
Airport Access
If flying out of Pearson, allow extra time for traffic on the 401 and 403.
Navigation
Use GPS with live traffic updates to navigate the complex highway interchanges.

Safety Tips

Aggressive Driving
Be prepared for high-speed, aggressive driving on the 401 near Toronto.
Lane Changes
Signal early and check blind spots frequently in heavy traffic.
Emergency Services
Keep the number for Ontario Provincial Police (OPP) handy for highway emergencies.
Visibility
Ensure your headlights are on during rain or overcast conditions.